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Kinetex 2.6µm PS C18 Core-Shell Column’s Chromatographic Performance and Unique Reversed Phase Selectivity in Comparison to a Conventional Fully Porous UHPLC Column

In this application, we investigated the Kinetex 2.6µm PS C18 HPLC/UHPLC column’s improved chromatographic performance and unique multi-interaction selectivity when applied to a screen of 36 tricyclic antidepressants (TCA). Because the Kinetex 2.6µm core-shell (superficially porous) particle morphology provides ultra-high column efficiency on any HPLC or UHPLC system1, the investigation also included a comparison to a conventual fully porous 1.9µm UHPLC column.