Analysis of California Residual Solvent Targets in Cannabis Extract (TN-2099)

The United States Pharmacopeia (USP) separates solvents into three different classes. The California Department of Cannabis Control (DCC) has outlined twenty-one solvents divided into two categories that must be tested on cannabis samples. It is important to note that the categories that the DCC have outlined do not necessarily coincide with the class system used by the USP. In this technical note, residual solvents were measured in both standard samples and a cannabis sample using headspace analysis. Standard sample results indicated high performance for all analytes with good linearity, area RSD, and IDL. These results also showed that the JEOL JMS-Q1500GC, using a Zebron™ ZB-624PLUS™ GC column, can easily handle the Category 1 residual solvents action limits set forth by the California DCC.