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Aggregate Analysis of Fc-Fusion Proteins using a Biozen dSEC-2 LC Column
Fc-fusion proteins are Fc homodimers linked to a polypeptide chain. From an analytical standpoint, Fcfusion proteins present several challenges. Fc-fusion proteins may have much more complex glycosylation, including deviations from the biantennary fucosylated glycans associated with monoclonal antibodies, as well as O-glycans.
Aggregate Analysis of Fc-Fusion Proteins using a Biozen dSEC-2 LC Column
Fc-fusion proteins are Fc homodimers linked to a polypeptide chain. From an analytical standpoint, Fcfusion proteins present several challenges. Fc-fusion proteins may have much more complex glycosylation, including deviations from the biantennary fucosylated glycans associated with monoclonal antibodies, as well as O-glycans.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Size Exclusion
Aggregate Analysis of Fc-Fusion Proteins using a Biozen dSEC-2 LC Column
Fc-fusion proteins are Fc homodimers linked to a polypeptide chain. From an analytical standpoint, Fcfusion proteins present several challenges. Fc-fusion proteins may have much more complex glycosylation, including deviations from the biantennary fucosylated glycans associated with monoclonal antibodies, as well as O-glycans.
| Target Industries: | Biopharmaceutical Analysis |
| Techniques: | HPLC |
| Brands: | Biozen LC |
| Separation Modes: | Size Exclusion |
| Phases: | Biozen Size Exclusion Chromatography (dSEC) Columns |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide