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Aggregate Analysis of Fc-Fusion Proteins using a Biozen dSEC-2 LC Column
Fc-fusion proteins are Fc homodimers linked to a polypeptide chain. From an analytical standpoint, Fcfusion proteins present several challenges. Fc-fusion proteins may have much more complex glycosylation, including deviations from the biantennary fucosylated glycans associated with monoclonal antibodies, as well as O-glycans.
Aggregate Analysis of Fc-Fusion Proteins using a Biozen dSEC-2 LC Column
Fc-fusion proteins are Fc homodimers linked to a polypeptide chain. From an analytical standpoint, Fcfusion proteins present several challenges. Fc-fusion proteins may have much more complex glycosylation, including deviations from the biantennary fucosylated glycans associated with monoclonal antibodies, as well as O-glycans.
Document Type:
Technical Notes
Target Industries:
Biopharmaceutical Analysis
Techniques:
HPLC
Brands:
Biozen LC
Separation Modes:
Size Exclusion
Phases:
Biozen Size Exclusion Chromatography (dSEC) Columns
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