Acids, Neutrals and Bases Using Novum Simplified Liquid Extraction (SLE) (TN-0121)

We developed a SLE application for acids (THC-COOH), neutrals (barbiturates), and bases (Norbuprenorphine and Buprenorphine) from a urine matrix containing ß-glucuronidase followed by two LC-MS/MS methods using a Kinetex EVO C18 LC column and SCIEX API 4000 mass spec in negative mode electrospray ionization (ESI-) and a Kinetex Biphenyl LC column and SCIEX API 4000 mass spec in positive mode electrospray ionization (ESI+).

Document Type:

Technical Notes

Target Industries:

Cannabis and Hemp, Clinical Research, Forensic Toxicology

Techniques:

Sample Preparation, Supported Liquid Extraction

Brands:

Kinetex, Novum

Separation Modes:

Reversed Phase, Supported Liquid Extraction

Phases:

Kinetex Biphenyl, Kinetex EVO C18