Low-pg/mL Quantification of Cyclic Peptides in Rat Plasma Using Microflow LC

In this study, human ANP was selected as a model analyte to evaluate improvement in sensitivity with the application of microflow LC. Low-level quantification was achieved for human ANP at an LLOQ of 0.01 ng/mL. The application of microflow LC yielded excellent accuracy, precision, and linearity, while providing outstanding quantitative performance in parallel with high sensitivity