Posted on Sep 25, 2025
Revolutionizing Midsize Biotherapeutic Characterization
September 30, 2025
Phenomenex continues to lead innovation in separation science with the launch of its latest addition to the Biozen portfolio: the Biozen dSEC-1 Size Exclusion Chromatography (SEC) column. Engineered specifically for the evolving needs of biopharmaceutical researchers, this column offers a powerful solution for analyzing midsize biomolecules such as peptides, oligonucleotides, and other emerging biotherapeutics.
As the demand for high-resolution aggregate analysis grows, scientists face challenges with traditional SEC columns that often introduce non-specific interactions and distorted chromatographic profiles. The Biozen dSEC-1 column overcomes these limitations with a highly inert surface and a robust silica-based matrix, enabling accurate separation and characterization of complex molecular species.
“The dSEC-1 column allowed us to resolve duplex, sense, and antisense strands of our siRNA targets with minimal interaction,” shared Jongsu Yoo, Senior Scientist at OliX Pharmaceuticals. “This level of resolution was not achievable with other SEC columns we’ve used.”
Why Biozen dSEC-1 Stands Out:
- Minimal analyte interaction for cleaner, more reliable chromatograms.
- Superior resolution across a wide molecular weight range.
- Durable media that supports higher back pressures and extended column life.
- Versatile compatibility with various mobile phases for flexible method development.
This new SEC column is ideal for researchers working in peptide therapeutics, nucleic acid-based drugs, and other midsize modalities where precision and reproducibility are critical. Whether you're profiling aggregates or characterizing structural variants, Biozen dSEC-1 delivers the performance needed to advance your analytical workflows.
Phenomenex remains committed to supporting scientific discovery with chromatography solutions that meet the demands of modern biotherapeutic development. Learn more about Biozen dSEC-1 and connect with our technical team on chat or Biozen dSEC-1
