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Robust Extractions of Phosphorothioate and Conjugated Oligonucleotides from Plasma and Liver Matrices Using Clarity OTX Microelution SPE
In this technical note, we investigate Clarity OTX solid phase extraction 2 mg/well microelution plate and Biozen Oligo 1.7 um LC column's performance in extracting and characterizing a GalNac-conjugated RNA duplex and Nusinersen, a phosphorothioate oligonucleotide.
Robust Extractions of Phosphorothioate and Conjugated Oligonucleotides from Plasma and Liver Matrices Using Clarity OTX Microelution SPE
In this technical note, we investigate Clarity OTX solid phase extraction 2 mg/well microelution plate and Biozen Oligo 1.7 um LC column's performance in extracting and characterizing a GalNac-conjugated RNA duplex and Nusinersen, a phosphorothioate oligonucleotide.
Document Type:
Technical Notes
Target Industries:
Brands:
Separation Modes:
Reversed Phase, Solid Phase Extraction
Phases:
Robust Extractions of Phosphorothioate and Conjugated Oligonucleotides from Plasma and Liver Matrices Using Clarity OTX Microelution SPE
In this technical note, we investigate Clarity OTX solid phase extraction 2 mg/well microelution plate and Biozen Oligo 1.7 um LC column's performance in extracting and characterizing a GalNac-conjugated RNA duplex and Nusinersen, a phosphorothioate oligonucleotide.
| Target Industries: | Biopharmaceutical Analysis |
| Techniques: | HPLC, HPLC Reversed Phase, Oligonucleotide Analysis, Solid Phase Extraction |
| Brands: | Biozen LC, ClaritySPE |
| Separation Modes: | Reversed Phase, Solid Phase Extraction |
| Phases: | Biozen-Oligo, Clarity OTX |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.