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Robust Analysis of Nitrosamines in a Losartan Drug Substance using Strata Activated Carbon Extraction
This tech note provides the optimized extraction protocol for the extraction of nitrosamines from a Losartan drug substance using Strata Activated
Carbon followed by GC-MS analysis. Traditional methods for analysis of nitrosamines require GC-MS/MS with a headspace capability to meet the low-level detection limits. With Strata Activated Carbon sample preparation and pseudo large volume injections, GC-MS was sufficient to achieve low-level detection of nitrosamines.
Robust Analysis of Nitrosamines in a Losartan Drug Substance using Strata Activated Carbon Extraction
This tech note provides the optimized extraction protocol for the extraction of nitrosamines from a Losartan drug substance using Strata Activated
Carbon followed by GC-MS analysis. Traditional methods for analysis of nitrosamines require GC-MS/MS with a headspace capability to meet the low-level detection limits. With Strata Activated Carbon sample preparation and pseudo large volume injections, GC-MS was sufficient to achieve low-level detection of nitrosamines.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Gas Chromatography
Phases:
Robust Analysis of Nitrosamines in a Losartan Drug Substance using Strata Activated Carbon Extraction
This tech note provides the optimized extraction protocol for the extraction of nitrosamines from a Losartan drug substance using Strata Activated
Carbon followed by GC-MS analysis. Traditional methods for analysis of nitrosamines require GC-MS/MS with a headspace capability to meet the low-level detection limits. With Strata Activated Carbon sample preparation and pseudo large volume injections, GC-MS was sufficient to achieve low-level detection of nitrosamines.
| Target Industries: | Biopharmaceutical Analysis, Clinical Research, Forensic Toxicology, Nitrosamine Analysis, Pharmaceutical |
| Techniques: | Gas Chromatography (GC), Sample Preparation |
| Brands: | Strata, Zebron GC Columns, Zebron Liners |
| Separation Modes: | Gas Chromatography |
| Phases: | Zebron ZB-WAXPLUS |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.