Robust Analysis of Nitrosamines in a Losartan Drug Substance using Strata™ Activated Carbon Extraction

Robust Analysis of Nitrosamines in a Losartan Drug Substance using Strata Activated Carbon Extraction

This tech note provides the optimized extraction protocol for the extraction of nitrosamines from a Losartan drug substance using Strata Activated Carbon followed by GC-MS analysis. Traditional methods for analysis of nitrosamines require GC-MS/MS with a headspace capability to meet the low-level detection limits. With Strata Activated Carbon sample preparation and pseudo large volume injections, GC-MS was sufficient to achieve low-level detection of nitrosamines.

Document Type:

Technical Notes

Target Industries:

Biopharmaceutical Analysis, Clinical Research, Forensic Toxicology, Nitrosamine, Pharmaceutical

Techniques:

GC, Sample Preparation

Brands:

Strata, Zebron GC Columns, Zebron Liners

Separation Modes:

Gas Chromatography

Phases:

Zebron ZB-WAXPLUS