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Kinetex Core-Shell Technology delivers dramatic improvements in efficiency over conventional fully porous media, which can be leveraged to increase resolution, significantly improve productivity, reduce solvent consumption, and decrease costs. Whether you are running high-performance liquid chromatography (HPLC) or ultra-high performance liquid chromatography (UHPLC) methods, the Kinetex core-shell family can deliver shockingly improved performance over the current column you are using. Phenomenex designs, manufactures, and sells its very own silica and organo-silica core-shell particles. Advantages of Kinetex HPLC columns:
Select a Phase to view products:
Hydrophilic Interaction
HILIC
Reversed Phase
Biphenyl
C8
C18
EVO C18
F5
PAH
PFP
Phenyl-Hexyl
Polar C18
PS C18
XB-C18
No Separation Mode
No Phase
Mixed Mode
Amide
Core-shell technology in chromatography is a revolutionary approach that enhances the efficiency of HPLC systems while minimizing costs. Core-shell particles are designed with a solid, non-porous silica core surrounded by a porous outer layer. This unique structure allows for faster analyte mass transfer between the mobile and stationary phases, as diffusion occurs only through the thin, porous shell rather than the entire particle. This minimizes band broadening, leading to higher separation efficiency and sharper peaks.
The consistency in size and shape of core-shell particles further enhances separation efficiency by reducing variability in analyte movement. As a result, core-shell HPLC columns provide high efficiency and resolution at lower backpressures, making them an ideal choice for labs looking to improve their existing HPLC systems without the need for costly UHPLC equipment.
Core-shell technology thus offers a cost-effective alternative to upgrading to UHPLC systems, enabling labs to maximize the efficiency of their current HPLC setups. The formation of these particles through advanced sol-gel processing techniques ensures uniformity and reliability, making them a valuable tool in modern chromatography. By using the Kinetex HPLC column, laboratories can achieve faster analysis times and higher productivity while maintaining excellent separation performance.
The 5 versatile particle sizes allow you to select the best fit for your instrument.
UHPLC
UHPLC
UHPLC/HPLC
HPLC
HPLC/PREP
Using sol-gel processing techniques that incorporate nano-structuring technology, a durable, homogeneous porous shell is grown on a solid silica core to create a Kinetex Core-Shell particle. This particle morphology results in less band broadening for all four sources of UHPLC band broadening compared to fully porous particles and thus delivers extremely high efficiencies.
Kinetex particles are characterized by an exceptionally consistent size distribution, with particles being nearly monodispersed, meaning they are uniform in size. This precise uniformity plays a crucial role in minimizing variability within the column, leading to enhanced separation efficiency and sharper peaks.
The nearly monodispersed nature of these particles ensures that the flow of the mobile phase remains consistent, reducing the likelihood of irregularities that can impact results. As a result, Kinetex columns deliver highly reliable and reproducible performance, making them ideal for achieving consistent analytical outcomes across various applications.
Minimized Band Broadening
Increased Band Broadening
Kinetex core-shell particle LC columns deliver exceptional performance enhancements across any LC system, offering unmatched efficiency and resolution. With a choice of 12 diverse stationary phases, these columns cater to a wide range of chromatographic applications, ensuring optimal separation for various analytes.
Additionally, the availability of five versatile particle sizes allows for precise method tailoring, enabling both high-speed and high-resolution separations. Whether you're using HPLC or UHPLC systems, Kinetex columns provide the flexibility and performance needed to achieve superior analytical results.
Polar Compounds
Polar Acids
Acidic Compounds
Hydrophobic Compounds
Alkaline Conditions
Polar Bases
Closely Related Compounds and Aromatic Hydrocarbons
Closely Related Compounds and Aromatic Hydrocarbons
Closely Related Compounds and Aromatic Hydrocarbons
Extremely Hydrophobic
PAH Compounds
Retention of extremely polar analytes
| Kinetex Phases | Shipping Solvent | Particle Sizes (µm) | Pore Size (Å) | Surface Area (m2/g) | Carbon Load (%) | pH Stability | Reversed Phase | Normal Phase | HILIC | 100% Aqueous Stable |
|---|---|---|---|---|---|---|---|---|---|---|
| Acetonitrile /100 mM Ammonium Formate pH 3.2 (90:10) | 2.6 | 100 | 200 | N/A | 2-7.5 | N | N | Y | Y | |
| Acetonitrile / Water (50:50) | 2.6 | 100 | 200 | 9 | 1.5-8.5* | Y | N | N | Y | |
| Acetonitrile / Water (50:50) | 2.6 | 100 | 200 | 9 | 1.5-8.5* | Y | N | N | Y | |
| Acetonitrile / Water (50:50) | 1.3, 1.7, 2.6, 5 | 100 | 200 | 12 | 1.5-8.5* | Y | N | N | N | |
| Acetonitrile / Water (45:55) | 1.7, 2.6, 5 | 100 | 200 | 11 | 1-12 | Y | N | N | Y | |
| Acetonitrile / Water (50:50) | 1.7, 2.6, 3.5, 5 | 100 | 200 | 10 | 1.5-8.5* | Y | N | N | N | |
| Acetonitrile / Water (45:55) | 1.7, 2.6, 5 | 100 | 200 | 8 | 1.5-8.5* | Y | N | N | N | |
| Acetonitrile/Water w/0.1 % Formic Acid (50:50) | 1.7, 2.6, 5 | 100 | 200 | 11 | 1.5-8.5* | Y | N | N | Y | |
| Acetonitrile / Water (45:55) | 1.7, 2.6, 5 | 100 | 200 | 11 | 1.5-8.5* | Y | N | N | N | |
| Acetonitrile / Water (40:60) | 1.7, 2.6, 5 | 100 | 200 | 9 | 1.5-8.5* | Y | N | N | Y | |
| Acetonitrile /100 mM Ammonium Formate (93:7) | 2.6 | 100 | 200 | 0 | 2.0-7.5 | N | Y | Y | N | |
| Acetonitrile / Water (65:35) | 3.5 | — | — | 12 | 1.5-8.5* | Y | N | N | N |
† Shipping conditions may vary slightly in terms of organic to aqueous ratio, depending on column dimensions. * pH stability under gradient conditions. pH stability is 1.5-10 under isocratic conditions.
****
Y=Yes
N=No
The combination of a consistent, solid, high-density core along with proprietary column packing technologies in the Kinetex HPLC column ensures optimum bed structure and high column performance. This carefully designed core structure promotes uniform packing of the particles, which is essential for minimizing band-broadening effects that can arise from Eddy Diffusion.
The manufacturing process of Kinetex columns is tightly controlled, focusing on factors such as particle size distribution, surface and bonding homogeneity, and packing quality. This meticulous engineering leads to uniform packing and minimized band-broadening, resulting in superior separation efficiency.
Kinetex 2.6 µm C18
Traditional 1.7 µm C18
50 x 2.1 mm
UV @ 254 nm
25 °C
0.6 mL/min
Acetonitrile / Water (50:50)
0.5 µL test mixture
Every step in the manufacturing process of Kinetex Core-Shell columns is tightly controlled for:
Kinetex 2.6 µm C18
50 x 4.6 mm
Water / Acetonitrile (65:35)
25 °C
UV @ 254 nm
1.0 mL/min
Comparative separations may not be representative of all applications.
Recommended Use
Enhanced separation of small polar compounds by HILIC or reversed phase modes
Core-shell with bonded biphenyl phase
Recommended Use
100 % aqueous stable reversed phase chemistry with hydrophobic, aromatic, and enhanced polar selectivity
Particle Size
5 µm, 2.6 µm, 1.7 µm
Core-shell with bonded C18 phase
Recommended Use
All-purpose hydrophobic retention and methylene selectivity
Particle Size
5 µm, 2.6 µm, 1.7 µm, 1.3 µm
Core-shell with bonded C8 phase
Recommended Use
Minimized hydrophobic retention for highly hydrophobic compounds
Particle Size
5 µm, 2.6 µm, 1.7 µm
Organo-silica core-shell with bonded C18 phase, resistant to extreme pHs
Recommended Use
High pH stability from 1-12 to deliver robust methods and improved peak shape for bases
Particle Size
5 µm, 2.6 µm, 1.7 µm
Core-shell with bonded pentafluorophenylpropyl phase
Recommended Use
Highly reproducible pentafluorophenylpropyl phase, exceptional for halogenated, conjugated, isomeric, or highly polar compounds.
Particle Size
5 µm, 2.6 µm, 1.7 µm
Unbonded core-shell silica
Recommended Use
Retention and separation of polar compounds hydrophilic interaction chromatography conditions
Particle Size
5 µm, 2.6 µm, 1.7 µm
Recommended Use
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Particle Size
5 µm, 2.6 µm
Core-shell with polymerically bonded C18 phase
Recommended Use
Polymerically bonded C18 phase specifically developed for the separation of EU and EPA priority PAHs.
Particle Size
3.5 µm
Core-shell bonded with pentafluorophenyl with TMS endcapping
Recommended Use
Ultra-high performance on UHPLC systems for aromatic and halogenated compounds
Particle Size
5 µm, 2.6 µm, 1.7 µm
Core-shell with bonded phenyl-hexyl phase
Recommended Use
Greater retention and separation of aromatic compounds
Particle Size
5 µm, 2.6 µm, 1.7 µm
Core-shell with polymerically bonded C18 phase
Recommended Use
Combined C18 and polar modified surface that provides polar and non-polar retention alongside 100% aqueous stability
Particle Size
2.6 µm
