Biozen Native RP-5

Enhanced ADC Characterization

Native RP-5, developed in tandem with Native RP-1, is an advanced chromatography column designed to revolutionize ADC DAR analysis through orthogonal reversed-phase separation under native conditions, facilitating direct MS detection. While traditional HIC methods offer reproducibility, they are hindered by long method times and high salt mobile phases that are incompatible with MS detection. Native reversed-phase analysis overcomes these challenges, providing comprehensive information that is essential for the development and consistent therapeutic performance of ADC therapeutics.

• Reduce Sample Manipulation: Eliminate fractionation and buffer exchange steps to reduce sample manipulation by 75% compared to traditional methods.
• Reproducible and Efficient: Achieve consistent resolution of DAR isoforms and reduce the number of ADC characterization methods by one-third.
• Enhanced Throughput: Improve high quality data to streamline critical throughput screening decisions