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What Catnip is Made of and Why it Can Make Your Cat Seem High
Explore the chemical compounds that go into why cats go crazy for catnip
Cats, from our domestic familiars to big cats like lions and tigers are susceptible to an oil found in the leaves and stems of Nepeta cataria, or the catnip plant. Rolling around, flipping over, and being generally hyperactive are several common behaviors that are exhibited by felines that smell catnip. But what exactly is in it that makes cats go bonkers?
The active chemical compound ingredient that attracts and effects your cat is Nepetalactone. Since it is concentrated in the leaves and stems, it is common to find cats gnawing on the plant to release more of the oil. Nepetalactone triggers a sense of euphoria in the brain of the susceptible cat, which produces the “high” that is sometimes described as similar to either marijuana or LSD in humans. The response to catnip typically lasts for about 10 minutes before wearing off.
The peculiar thing about catnip is that the behaviors described above only occur when a cat smells the oil. When it is eaten, it acts as a sedative and many researchers believe it is because the oil mimics feline pheromones and is triggering those receptors. However, not all cats feel the effects of catnip. About 70 to 80 percent of cats seem to be affected and the behavioral reactions of catnip vary between individuals. It is thought that sensitivity, or lack thereof, to catnip is hereditary.
Catnip isn’t just for cats either. Nepeta cataria is also known to help humans and has been used for its sedative properties for centuries. It has similar properties to chamomile and is also a very potent mosquito repellent. Luckily, cats cannot overdose on catnip, but that doesn’t mean you don’t want to know if what your cat is rolling around in is safe for them.
If detection of chemical compounds in your pet’s nip, toys, and food is of interest to you and your next application, check out these resources:
Analysis of FAMEs in Salmon Oil and Pet Food
Zebron ZB-5MSplus GC Columns
Extraction of Melamine From Pet Food
Author
Our Phenomenex Team
Our Phenomenex Team
The Phenomenex Team is a group of dedicated scientists and chromatography specialists passionate about helping researchers succeed. With decades of combined experience in analytical chemistry, method development, and troubleshooting, we deliver practical insights, innovative solutions, and educational resources to support laboratories worldwide. From LC and GC to sample preparation and cutting-edge technologies, our experts make complex topics approachable and actionable—guiding you every step of the way.
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